a study of anomaly producing effects of disodium hemiphtalate glycyrrhetinic acid on skleton of mice embryo

disodium hemiphthalate glycyrrhetinic acid (dhga) possesses anti-inflammatory and analgestic activities. in our research, this agent was injected intraperitoneally to mice, according to the following schedule.1) 25 mg/kg, 50mg/kg & 75mg/kg at 7th day of pregnancy.2) 50 mg/kg & 75mg/kg at 8th day of pregnancy.3) 50mg/kg & 75mg/kg at 9th day of pregnancy.dhga with doses of 50mg/kg and 75mg/kg at 7th, 8th and 9th day, delays the growth, decreases developing of ossification centers (specially in hand and foot middle phalanxes), decreases the number of caudal vertebrae of sacro-illiac joint and results in slight but important increases in fetus mortality.abbreviationsh & e=haematoxylin & eosincrl=crown-rump lengthbpd=biparietal diameterw=weightets=embryo toxicity score